Serveur d'exploration sur la grippe en Espagne

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Clinical presentation and prognosis of the 2009 H1N1 influenza A infection in HIV-1-infected patients: a Spanish multicenter study.

Identifieur interne : 000491 ( Main/Exploration ); précédent : 000490; suivant : 000492

Clinical presentation and prognosis of the 2009 H1N1 influenza A infection in HIV-1-infected patients: a Spanish multicenter study.

Auteurs : Melchor Riera [Espagne] ; Antoni Payeras ; Maria A. Marcos ; Diego Viasus ; Maria C. Farinas ; Ferran Segura ; Julian Torre-Cisneros ; Alejandro Martín-Quir S ; Jesús Rodríguez-Ba O ; Juan Vila ; Elisa Cordero ; Jordi Carratalà

Source :

RBID : pubmed:20827165

Descripteurs français

English descriptors

Abstract

OBJECTIVE

The aim of the study was to describe the clinical presentation and prognosis in HIV-1-infected patients with hospital admission and pandemic influenza A 2009 (H1N1) confirmed, and compare this data with those of a general population.

DESIGN

: This is a prospective study in nature.

METHODS

All adult patients admitted to 13 hospitals in Spain with confirmed influenza A 2009(H1N1) virus infection by real-time reverse transcriptase PCR assay or culture from June 12 to November 10, 2009 were recruited and followed up until 1 month after discharge. In the HIV group risk factors for HIV infection, AIDS criteria, last CD4 cell count and viral load, and antiretroviral therapy and pneumococcal vaccines were collected.

RESULTS

Five hundred and eighty-five patients were recruited, 26 with HIV-1 infection and 559 non-HIV. The HIV patients had a long-term well controlled infection with a median CD4 cell count 503 cells/μl and 84% with undetectable viral load, although more frequently they had chronic liver and chronic obstructive pulmonary disease. No significant differences were observed about reported symptoms and physical findings on hospital admission. About 50% of patients in both groups present radiological infiltrates and 30% present respiratory failures. Practically all the patients in both groups received influenza antiviral therapy and in each group 80% received antibacterial therapy. No differences were observed in clinical outcomes.

CONCLUSION

In HIV patients, well controlled on HAART, the pandemic influenza virus AH1N1 had a similar clinical outcome and prognosis to that of non-HIV patients.


DOI: 10.1097/QAD.0b013e32833e508f
PubMed: 20827165


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<b>OBJECTIVE</b>
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<p>The aim of the study was to describe the clinical presentation and prognosis in HIV-1-infected patients with hospital admission and pandemic influenza A 2009 (H1N1) confirmed, and compare this data with those of a general population.</p>
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<b>DESIGN</b>
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<b>METHODS</b>
</p>
<p>All adult patients admitted to 13 hospitals in Spain with confirmed influenza A 2009(H1N1) virus infection by real-time reverse transcriptase PCR assay or culture from June 12 to November 10, 2009 were recruited and followed up until 1 month after discharge. In the HIV group risk factors for HIV infection, AIDS criteria, last CD4 cell count and viral load, and antiretroviral therapy and pneumococcal vaccines were collected.</p>
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<p>
<b>RESULTS</b>
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<p>Five hundred and eighty-five patients were recruited, 26 with HIV-1 infection and 559 non-HIV. The HIV patients had a long-term well controlled infection with a median CD4 cell count 503 cells/μl and 84% with undetectable viral load, although more frequently they had chronic liver and chronic obstructive pulmonary disease. No significant differences were observed about reported symptoms and physical findings on hospital admission. About 50% of patients in both groups present radiological infiltrates and 30% present respiratory failures. Practically all the patients in both groups received influenza antiviral therapy and in each group 80% received antibacterial therapy. No differences were observed in clinical outcomes.</p>
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<b>CONCLUSION</b>
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<p>In HIV patients, well controlled on HAART, the pandemic influenza virus AH1N1 had a similar clinical outcome and prognosis to that of non-HIV patients.</p>
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<li>Espagne</li>
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<name sortKey="Carratala, Jordi" sort="Carratala, Jordi" uniqKey="Carratala J" first="Jordi" last="Carratalà">Jordi Carratalà</name>
<name sortKey="Cordero, Elisa" sort="Cordero, Elisa" uniqKey="Cordero E" first="Elisa" last="Cordero">Elisa Cordero</name>
<name sortKey="Farinas, Maria C" sort="Farinas, Maria C" uniqKey="Farinas M" first="Maria C" last="Farinas">Maria C. Farinas</name>
<name sortKey="Marcos, Maria A" sort="Marcos, Maria A" uniqKey="Marcos M" first="Maria A" last="Marcos">Maria A. Marcos</name>
<name sortKey="Martin Quir S, Alejandro" sort="Martin Quir S, Alejandro" uniqKey="Martin Quir S A" first="Alejandro" last="Martín-Quir S">Alejandro Martín-Quir S</name>
<name sortKey="Payeras, Antoni" sort="Payeras, Antoni" uniqKey="Payeras A" first="Antoni" last="Payeras">Antoni Payeras</name>
<name sortKey="Rodriguez Ba O, Jesus" sort="Rodriguez Ba O, Jesus" uniqKey="Rodriguez Ba O J" first="Jesús" last="Rodríguez-Ba O">Jesús Rodríguez-Ba O</name>
<name sortKey="Segura, Ferran" sort="Segura, Ferran" uniqKey="Segura F" first="Ferran" last="Segura">Ferran Segura</name>
<name sortKey="Torre Cisneros, Julian" sort="Torre Cisneros, Julian" uniqKey="Torre Cisneros J" first="Julian" last="Torre-Cisneros">Julian Torre-Cisneros</name>
<name sortKey="Viasus, Diego" sort="Viasus, Diego" uniqKey="Viasus D" first="Diego" last="Viasus">Diego Viasus</name>
<name sortKey="Vila, Juan" sort="Vila, Juan" uniqKey="Vila J" first="Juan" last="Vila">Juan Vila</name>
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<country name="Espagne">
<noRegion>
<name sortKey="Riera, Melchor" sort="Riera, Melchor" uniqKey="Riera M" first="Melchor" last="Riera">Melchor Riera</name>
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</country>
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